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It immediately floods the brain and reaches peak levels somewhere between 30 minutes and two hours after administration thanks to etizolam’s excellent absorption in the digestive system. Its plasma half-life is 3.5 hours, whereas that of its active metabolite, alpha-hydroxyetizolam, is over 8 hours. An essential measure of an action’s duration is its half-life. The effects of etizolam peak at about 3 to 4 hours and can last for a total of 6 to 8 hours.
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